Organic Synthesis and Methodology
The Leonori Research Group
  • Home
  • The Group
    • Former Group Members
    • Group Awards
  • Research
  • Publications
  • Daniele
  • Pictures
    • The Lab
    • PhD Vivas
    • Group Meetings
  • Contacts
61) E. Rivera-Chao, J. Corpas, G. Lonardi, V. Derdau, A. Ruffoni, and D. Leonori*
Excited-State Basicity Diverts the Site-Selectivity of Aromatic Deuteration: Application to the Late-Stage Labelling of Pharmaceuticals

Angew. Chem. Int. Ed. 2025, Accepted Article
Picture

Picture
60) W. J. Olivier, P. T. Blyszczyk, E. M. Arpa, K. Hitoshio,  M. Gomez-Mendoza, V. De la Peña O'Shea, I. Marchand, T. Poisson, A. Ruffoni,* and D. Leonori*
 Excited-State Configuration of Nitroarenes Enables Oxidative Cleavage of Aromatics over Alkenes
​
Science 2025, 387, 1167–1174
Picture

59) R. Güdük, N. Kehl, C. Stavagna, M. J. Tilby, O. Turner, A. Ruffoni,* H. P. Caldora* and D. Leonori*
A Three-step Strategy for the Conversion of Pyridines into Benzonitriles
​
Nat. Synth. 2025, ASAP 

Synfacts Highlight by  P. Richardson @ Synfacts 2025, 21,  454
Picture

58) P. T. Blyszczyk and  D. Leonori*
Photochemical Oxidative Cleavage and Dihydroxylation of Unsaturated Fatty Acids using Triplet Nitroarenes 
Eur. J. Lipid Sci. Technol. 2025, Early View
Picture

57) T. dos Santos, C. S. Buettner​, D. Berna Yildiz, M. Mamone, A. Ruffoni and  D. Leonori*
Photochemical Conversion of Indazoles into Benzimidazoles
Angew. Chem. Int. Ed. 2025, Accepted Article
Picture

Picture
56) B. Roure, M. Alonso, G. Lonardi,  D. Berna Yildiz, C. S. Buettner, T. dos Santos, Y. Xu, M. Bossart,  V. Derdau, M. Méndez, J. Llaveria, A. Ruffoni* and  D. Leonori*
Photochemical Permutation of Thiazoles, Isothiazoles and Other Azoles
Nature 2024, 637, 860–8670

Highlight by R. Dabas @ ChemistryWorld
Picture

Picture
55) J. Corpas, E. Rivera-Chao, E. M. Arpa, M. Gomez-Mendoza, Y. Katayama, V. A. de la Peña O’Shea, C. Bouchel, C. Jacob, P.-G. Echeverria, A. Ruffoni,  D. Leonori*
Excited-state Protonation and Reduction Enables the Umpolung Birch Reduction of Naphthalenes
Chem 2025, 11, 102342

​
Highlight by Org. Process. Res. Dev. 2025, 29, 225–236
​Synfacts Highlight by B. List and L. Alama @ Synfacts 2025, 21, 186
Picture

Picture
54) J. Corpas, M. Alonso and  D. Leonori*
Boryl Radical-Mediated Halogen-Atom Transfer (XAT) Enables the Sonogashira-Like Alkynylation of Alkyl Halides 
Chem. Sci.  2024, 15, 19113–19118
Picture

Picture
53) C. S. Buettner, C. Stavagna, M. J. Tilby, B. Górski, J. J. Douglas, N. Yasukawa* and  D. Leonori*
Synthesis and Suzuki–Miyaura Cross-Coupling of Alkyl Amine-Boranes. A Boryl Radical-Enabled Strategy
J. Am. Chem. Soc.  2024, 146, 24042–24052
Picture

Picture
52) Z. Zhang,  L. Poletti and  D. Leonori*
A Radical Strategy for the Alkylation of Amides with Alkyl Halides by Merging Boryl Radical-Mediated Halogen-Atom Transfer and Copper Catalysis
J. Am. Chem. Soc. 2024, 146, 22423–22430

Highlight by Org. Process. Res. Dev. 2024, 28, 3439–3449
Picture

Picture
51) Z. Zhang,  M. J. Tilby and  D. Leonori*
Boryl Radical-mediated Halogen-Atom Transfer Enables Arylation of Alkyl Halides with Electrophilic and Nucleophilic Coupling Partners
Nat. Synth. 2024,  3, 1221–1230
Picture

Picture
​50) J. Corpas, H. P. Caldora, E. M. Di Tommaso, A. C. Hernandez-Perez, O. Turner, L. M. Azofra, A. Ruffoni* and  D. Leonori*
A General Strategy for the Amination of Electron-rich and Electron-poor Heteroaromatics by Desaturative Catalysis 
Nat. Catal. 2024, 7, 593–603


Highlight by Org. Process. Res. Dev. 2024, 28, 2367–2381
​
Synfacts Highlight by P. Richardson @ Synfacts 2025, 21, 235
​
Picture

Picture
49) R. Sánchez-Bento, L. Bui, V. K. Duong, A. Ruffoni* and  D. Leonori*
A Photochemical Strategy for the Synthesis of Caprolactams via Dearomative Ring Expansion of Nitroarenes
Synthesis 2024, 56, A–G
​

Highlight by D. F. Taber @ Org. Chem. Highlights

​Special Issue PSRC-10 (10th Pacific Symposium on Radical Chemistry) ​

​

Picture

Picture
​48) R. Mykura, R. Sánchez-Bento, E. Matador, V. K. Duong, A. Valera, L. Angelini, R. J. Carbajo, J. Llaveria,  A. Ruffoni* and  D. Leonori*
Synthesis of Polysubstituted Azepanes by Dearomative Ring Expansion of Nitroarenes
Nat. Chem. 2024, 16, 771–779

Synfacts Highlight by D. Trauner and A. Sailer @ Synfacts 2024, 20, 0420
Picture

Picture
​47) E. Matador, M. J. Tilby, I. Saridakis, M. Pedrón, D. Tomczak, J. Llaveria, I. Atodiresei, P. Merino*, A. Ruffoni* and  D. Leonori*
A Photochemical Strategy for the Conversion of Nitroarenes into Rigidified Pyrrolidine Analogues
J. Am. Chem. Soc. 2023, 150,  27810–27820

Synfacts Highlight by D. Zhao and T. Xiao @ Synfacts 2024, 20, 0358
Picture

Picture
46) B. Li,  A. Ruffoni* and  D. Leonori*
A Photochemical Strategy for ortho-Aminophenol Synthesis via Dearomative-Rearomative Coupling Between Aryl Azides and Alcohols
Angew. Chem. Int. Ed.  2023, 62, e202310540

Synfacts Highlight by A. F. Stepan and T. R. Puleo @ Synfacts 2024, 20, 0203
Picture

Picture
​45) R. Sánchez-Bento, B. Roure, J. Llaveria, A. Ruffoni* and  D. Leonori*
A Strategy for ortho-Phenylenediamine Synthesis via Dearomative-Rearomative Coupling of Nitrobenzenes and Amines 
Chem 2023, 9, 3685 –3695
​

Synfacts Highlight by M. Reed and M. Allen @ Synfacts 2024, 20, 0120
Picture

Picture
​44) H. Caldora,  Z. Zhang,  M. J. Tilby,  O. Turner and  D. Leonori*
Dual Photochemical H-Atom Transfer and Cobalt Catalysis for the Desaturative Synthesis of Phenols from Cyclohexanones
Angew. Chem. Int. Ed. 2023, 62, e202301656
Picture

Picture
43) L. Caiger,  H. Zhao,  T. Constantin,  J. J. Douglas and  D. Leonori*
The Merger of Aryl Radical-Mediated Halogen-Atom Transfer (XAT) and Copper Catalysis for the Modular Cross-Coupling-Type Functionalization of Alkyl Iodides
ACS  Catal. 2023, 13, 4985–4991
Picture

Picture
​42) C. Hampton, M. Simonetti* and D. Leonori*
Olefin Dihydroxylation Using Nitroarenes as Photoresponsive Oxidants
Angew. Chem. Int. Ed. 2023, 62,  e202214508
​

Highlight by J. C. L. Walker @ Nachrichten aus der Chemie 2024, 72, 70-73
Picture

Picture
​41) S. Govaerts, K. Nakamura, T. Constantin* and D. Leonori*
A Halogen-Atom Transfer (XAT)-Based Approach to Indole Synthesis Using Aryl Diazonium Salts and Alkyl Iodides
Org. Lett. 2022, 24, 7883–7887


​Winner of the Organic letter Outstanding Publication Award (2023)
Picture

Picture
​40) T. Constantin, B. Górski, M. Tilby, S. Chelli, F. Julia, J. Llaveria, K. J. Gillen, H. Zipse, S. Lakhdar* and D. Leonori*
Halogen-atom and Group Transfer Reactivity enabled by Hydrogen Tunneling
Science 2022, 377, 1323–1328

Highlight by CNRS @ CNRS
Synfacts Highlight by B. List and M. Guillen @ Synfacts 2022, 18, 1353
Picture

Picture
​39) A. Ruffoni, C. Hampton, M. Simonetti* and D. Leonori*
Photoexcited Nitroarenes for the Oxidative Cleavage of Alkenes
Nature 2022, 610, 81–86

Highlight by J. C. L. Walker Nachrichten aus der Chemie 2024, 72, 70-73
Nature News & Views: V. Palani and A. Wendlandt Nature 2022, 610, 40-41
Highlight by D. Lowe @ In the Pipeline
Highlight by That Chemist @ YouTube
Picture

Picture
38) A. Ruffoni, R. Mykura, M. Bietti and D. Leonori*
The Interplay of Polar Effects in Controlling the Selectivity of Radical Reactions
Nat. Synth.
 2022, 1, 682–695
Picture

Picture
37) H. Zhao, H. Caldora, O. Turner, J. J. Douglas and D. Leonori*
A Desaturative Approach for Aromatic Aldehyde Synthesis via Synergistic Enamine, Photoredox and Cobalt Triple Catalysis
Angew. Chem. Int. Ed. 2022, 61, e2022018

Selected as "Hot Paper"
Highlight by Org. Process. Res. Dev. 2022, 26, 1547
Picture

Picture
36) Z. Zhang, B. Górski and D. Leonori*
Merging Halogen-Atom Transfer (XAT) and Copper Catalysis for the Modular Suzuki–Miyaura-Type Cross-Coupling of Alkyl Iodides and Organoborons
J. Am. Chem. Soc.
 2022, 144, 1986–1992


Highlight by D. F. Taber @ Org. Chem. Highlights
Picture

Picture
35) T. Constantin, F. Julia and D. Leonori*
Applications of Halogen-Atom Transfer (XAT) for the Generation of Carbon Radicals in Synthetic Photochemistry and Photocatalysis
Chem. Rev. 2022, 122, 2292–2352
Picture

Picture
​34) H. Zhao, A. J. McMillan, T. Constantin, R. Mykura, F. Julia and D. Leonori*
Merging Halogen-Atom Transfer (XAT) and Cobalt Catalysis to Override E2-Selectivity in the Elimination of Alkyl Halides: A Mild Route toward contra-Thermodynamic Olefins
J. Am. Chem. Soc. 
2021, 143, 14806–14813

Highlight by D. F. Taber @ ​Org. Chem. Highlights
Picture

Picture
33) B. Górski, A.-L. Barthelemy, J. J. Douglas, F. Julia* and D. Leonori*
Copper-Catalysed Amination of Alkyl Iodides Enabled by Halogen-Atom Transfer
Nat. Catal. 
2021, 4, 623–630

Highlight by D. F. Taber @ Org. Chem. Highlights
Picture

Picture
32) L. Caiger, C. Sinton, T. Constantin, J. J. Douglas, N. S. Sheikh, F. Julia and D. Leonori*
Radical Hydroxymethylation of Alkyl Iodides Using Formaldehyde as a C1 Synthon
Chem. Sci. 2021, 12, 10448–10454
Picture

Picture
31) H. P. Caldora, S. Govaerts, S. U. Dighe, O. J. Turner and D. Leonori*
A de novo Synthesis of Oxindoles from Cyclohexanone-Derived g-Keto-Ester Acceptors Using a Desaturative Amination-Cyclization Approach
Synthesis
 2021​, 53, 4272–4278


Special Issue dedicated to Prof. Sarah Reisman, recipient of the 2019 Dr. Margaret Faul Women in Chemistry Award
Picture

Picture
30) J. H. Kim, T. Constantin, M. Simonetti, J. Llaveria, N. S. Sheikh and D. Leonori*
A Radical Approach for the Selective  C–H  Borylation of Azines
Nature 
2021, 595, 577–584

Nature News & Vi
ews: C. Le Nature 2021, 595, 652-653
Highlight by S. Yang and J. Ye Chem 2021, 7, 1703–1705
Synform Highlight by M. Zanda Synform 2021|10, A162-A165
Highlight by Org. Process. Res. Dev. 2022, 25, 1997
Picture

Picture
29) H. Zhao and D. Leonori*
Minimization of Back-Electron Transfer Enables the Elusive sp3 C–H Functionalization of Secondary Anilines
Angew. Chem. Int. Ed. 2021, 60, 7669-7674

Highlight by D. F. Taber @ Org. Chem. Highlights
Picture

Picture
Picture
28) A. J. McMillan, M. Sieńkowska, P. Di Lorenzo, G. K. Gransbury, N. F. Chilton, M. Salamone, A. Ruffoni*, M. Bietti* and D. Leonori*
Practical and Selective sp3 C–H Chlorination via Aminium Radicals
Angew. Chem. Int. Ed. 2021, 60, 7132–7139

Selected as VIP Article.

Highlight by ChemistryViews Photoinduced Selective sp3 C–H Chlorination
Picture

Picture
27) T. Constantin, F. Julia, N. S. Sheikh and D. Leonori*
A Case of Chain Propagation: a-Aminoalkyl Radicals as Initiators for Aryl Radical Chemistry
Chem. Sci. 2020, 11, 12822-12828


Highlight by Org. Process. Res. Dev. 2020, 24, 2789
Picture

Picture
26) S. Dighe, F. Julia, A. Luridiana, J. J. Douglas and D. Leonori*
A Photochemical Dehydrogenative Strategy for Aniline Synthesis
Nature 2020, 584, 75-82


Nature News & Views: V. A. Schmidt Nature 2020, 584, 46-47
Highlight by B. Yirkaa @ Phys.org
Highlight by L. K. Boerner @ C&EN
Highlight by K. Welter @ ChemistryWorld

Highlight by the Cyclo Edition @ YouTube
Highlight by D. Trauner and B. S. Matsuura @ Synfact 2020, 16, 1361
Highlight by Galchimia
Picture

Picture
25) S. Govaerts, L. Angelini, C. Hampton, L. Malet-Sanz, A. Ruffoni* and D. Leonori*
Photoinduced Olefin Diamination with Alkylamines
Angew. Chem. Int. Ed. 2020, 59, 15021-15028

Highlight by D. Trauner and B. S. Matsuura @ Synfact 2020, 16, 977
Picture
Picture
24) T. Constantin, M. Zanini, A. Regni, N. S. Shikh, F. Julia'* and D. Leonori*
Aminoalkyl Radicals as Halogen-Atom Transfer Agents for Activation of Alkyl and Aryl Halides
Science 2020, 367, 1021–1026

Highlight by X.-S. Zhou, D.-M. Yan and J.-R. Chen Chem 2020, 6, 823–825
Picture
Picture
23) F. Julia, A. Ruffoni and D. Leonori*
​Aromatic C–H Amination Using Alkyl Amines
​Trends in Chemistry 2020, 2, 480-481

Invited Contribution for the "Mechanism of the Month"
Picture
22) J. H. Kim, A. Ruffoni, Y. S. S. Al-Faiyz, N. S. Sheikh* and D. Leonori*
​Divergent Strain-Release Amino-Functionalization of [1.1.1]-Propellane with Electrophilic Nitrogen Radicals
​Angew. Chem. Int. Ed. 2020, 59, 8225-8231


Highlight by P. Knochel and J. H. Harenberg @ Synfact 2020, 16, 423
Picture
Picture
21) L. Angelini, L. Malet-Sanz and D. Leonori*
​
Divergent Nickel-Catalysed Ring-Opening–Functionalisation of Cyclobutanone Oximes with Organozincs
Synlett 2020, 31, 37-40

Invited Contribution for the themed collection "9th Pacific Symposium on Radical Chemistry"
Picture
Picture
20) E. M. Dauncey, S. U. Dighe, J. J. Douglas and D. Leonori*
A Dual Photoredox-Nickel Strategy for Remote Functionalization via Iminyl Radicals: Radical Ring-Opening–Arylation, –Vinylation and –Alkylation Cascades
Chem. Sci. 
2019, 10, 7728–7733
Picture
Picture
19) A. Ruffoni, F. Julia, T. D. Svejstrup, A. McMillan, J. J. Douglas and D. Leonori*
Practical and Regioselective Amination of Arenes Using Alkylamines
Nat. Chem. 2019, 11, 426–433

Highlight by D. Nagib Nat. Chem. 2019, 11, 396
Highlight by AstraZeneca Lighting the Path to Simplified Chemical Reactions

Highlight by the Cyclo Edition @  Youtube
​Highlight by M. Zanda Synform 2019, 10, A157
Highlight by AtraZeneca @ ChemistryWorld
Picture
Picture
18) F. Julia and D. Leonori*
Oxygen Heterocycles: Fluorescein, Rhodamines, Rose Bengal
Photoorganocatalysis in Organic Synthesis 
2019, 287
Picture
Picture
17) L. Angelini, J. Davies, M. Simonetti, L. Malet-Sanz, N. S. Sheikh and D. Leonori*
Reaction of Nitrogen-Radicals with Organometallics Under Ni-Catalysis: N-Arylations and Amino-Functionalization Cascades
Angew. Chem. Int. Ed. 2019, 58, 5003-5007


Selected as "Hot Paper"
Highlight by ChemistryViews Nitrogen Radicals and Organometallics Collide
Highlight by P. Knochel and S. Graßl @ Synfacts 2019, 15, 514
Highlight by Org. Process. Res. Dev. 2019, 23, 683
Picture
Picture
16) D. C. Marcote, R. Street-Jeakings, E. Dauncey, J. J Douglas, A. Ruffoni* and D. Leonori*
Photoinduced Decarboxylative Azidation of Cyclic Aminoacids
Org. Biomol. Chem. 2019, 17, 1839-1842

Invited Contribution for the themes collection "New Talent"
Highlight by V. Snieckus and A. Davies @ 
Synfacts 2019, 15, 352
Picture
Picture
15) D. Leonori and R. E. Sturgeon*
A Unified Approach to Mechanistic Aspects of Photochemical Vapor Generation
J. Anal. At. Spectrom. 
2019, 34, 636-654

Tutorial Review
Picture
14) A. Ruffoni and D. Leonori*
Photocatalytic Carbon—Heteroatom Bond Formation
Science of Synthesis 2019, 517
Picture
13) S. P. Morcillo, E. D. Dauncey, J. H. Kim, J. J. Douglas, N. S. Sheikh and D. Leonori* 
Photoinduced Remote Functionalization of Amides and Amines Using Electrophilic Nitrogen-Radicals
Angew. Chem. Int. Ed. 2018, 57, 12945-12949


Highlight by D. F. Taber @​ Org. Chem. Highlights ​
Picture
Picture
12) J. Davies, S. P. Morcillo, J. J. Douglas and D. Leonori* 
Hydroxylamine Derivatives as Nitrogen-Radical Precursors in Visible-Light Photochemistry
Chem. Eur. J. 2018, 24, 12154-12163
Frontispiece

​
Invited Concept Article for "Young Chemists Special Issue"
Picture
Picture
11) J. Davies, L. Angelini, M. A. Alkhalifah, L. Malet Sanz, N. S. Sheikh* and D. Leonori* 
Photoredox Synthesis of Aryl-Hydroxylamines from Carboxylic Acids and Nitrosoarenes
Synthesis 
2018, 50, 821-830
​
Invited submission for special issue "Bürgenstock Special Section 2017 Future Stars in Organic Chemistry"
Highlight by Synform
Picture
Picture
Picture
10) E. M. Dauncey, S. P. Morcillo, J. J. Douglas, N. S. Sheikh and D. Leonori* 
Photoinduced Remote Functionalizations via Iminyl Radical-Promoted C–C and C–H Bond Cleavage Cascades
​Angew. Chem. Int. Ed. 2018, 57, 744-748


Highlight by ChemistryViews Accessing Elusive Molecular Carbon Radicals
Highlight by D. F. Taber @ Org. Chem. Highlights 
Picture
Picture
Picture
9) T. D. Svejstrup, A. Ruffoni, F. Juliá, V. M. Aubert and D. Leonori* 
Synthesis of Arylamines via Aminium Radicals
Angew. Chem. Int. Ed. 2017, 56, 14948-14952

​
Highlight by ChemistryViews Direct Amination of Unfunctionalised Aromatics
Picture
Picture
8) J. Davies, N. S. Sheikh and D. Leonori* 
Photoredox Imino-Functionalizations of Olefins
Angew. Chem. Int. Ed. 2017, 56, 13361-13365
​

Highlight by B. List and S. Schwengers @ Synfact 2017, 13, 1205
Picture
Picture
7) D. Fernandez Reina, A. Ruffoni, Y. S. S. Al-Faiyz, J. Douglas, N. S. Sheikh* and D. Leonori* 
Visible-Light-Mediated Reactions of Electrophilic Radicals with Vinyl and Allyl Trifluoroborates
ACS Catal. 2017, 7, 4126-4130
Picture
Picture
6) D. Fernandez Reina, E. M. Duncey, S. P. Morcillo, T. D. Svejstrup, M. V. Popescu, J. Douglas, N. S. Sheikh* and D. Leonori* 
Visible-Light-Mediated 5-exo-dig Cyclizations of Amidyl Radicals
Eur. J. Org. Chem. 2017, 2108-2111
​

Invited Contribution for special issue on photoredox catalysis
Picture
Picture
5) T. D. Svejstrup, W. Zadownly, D. Bidgelli, J. Douglas, N. S. Sheikh and D. Leonori* 
Visible-Light-Mediated Generation of Nitrile Oxides for the Photoredox Synthesis of Isoxazolines and Isoxazoles
Chem. Commun. 
2016, 52, 12302-12305
Picture
Picture
4) T. P. Nicholls, D. Leonori* and A. C. Bissember*
Applications of visible light photoredox catalysis to the synthesis of natural products and related compounds
Nat. Prod. Rep. 2016, 33, 1248-1254
Picture
Picture
3) J. Davies, T. D. Svejstrup, D. Fernandez Reina, N. S. Sheikh and D. Leonori*
Visible-Light-Mediated Synthesis of Amidyl Radicals: Transition Metal-Free Hydroamination and N-Arylation Reactions

J. Am. Chem. Soc. 2016, 138, 8092-8095

Highlight by Org. Process. Res. Dev. 2016, 20, 1393
Picture
Picture
​​2) J. Davies, S. G. Booth, S. Essafi, R. W. A. Dryfe and D. Leonori* 
Visible Light-Mediated Generation of Nitrogen-Centered Radicals: Metal-Free Hydroimination- and Iminohydroxylation-Cyclization Reactions​ 
Angew. Chem. Int. Ed. 2015, 54, 14017-14021
Picture
Picture
1) J. Davies and D. Leonori* 
The First Calcium-Catalysed Nazarov 
Cyclis​ation
Chem. Commun. 2014, 50, 15171-15174
Picture

PhD and Postdoc

University of Bristol

23) A. Varela, L. Garve, D. Leonori* and V. K. Aggarwal*
Stereocontrolled Total Synthesis of (–)-Stemaphylline
Angew. Chem. Int. Ed. 2017, 129
, 2159-2163.

22) M. Odachowski, A. Bonet, S. Essafi, P. Conti-Ramsden, J. N. Harvey*, D. Leonori* and V. K. Aggarwal*
Development of Enantiospecific Coupling of Secondary and Tertiary Boronic Esters with Aromatic Compounds
J. Am. Chem. Soc. 2016, 138, 9521-9532.

21) J. Llaveria, D. Leonori and V. K. Aggarwal*
Stereospecific Coupling of Boronic Esters with N‐Heteroaromatic Compounds
J. Am. Chem. Soc. 2015, 137, 10958-10961.

20) D. Leonori* and V. K. Aggarwal*
Stereospecific Cross-Couplings of Organoborons 
Angew. Chem. Int. Ed. 2014, 54, 1082-1096.

19) D. Leonori and V. K. Aggarwal* 
Lithiation-Borylation and its Application in Synthesis
Acc. Chem. Res. 2014, 47, 3174-3183.

18) P. Unsworth, D. Leonori and V. K. Aggarwal* 
Stereocontrolled Synthesis of 1,5-Stereogenic Centers through Three-Carbon Homologation of Boronic  Esters
Angew. Chem. Int. Ed. 2014, 53, 9846-9850.
This paper was selected by the Editors as VIP.             

17) A. Bonet, M. Odachovski, D. Leonori, S. Essafi and V. K. Aggarwal* 
Enantiospecific coupling of secondary & tertiary boronic esters
Nat. Chem. 2014, 6, 584-589.
This paper was highlighted in C&EN.
This paper was highlighted in Chemistry World.
This paper was highlighted in Synfacts.

16) S. Roesner, C. Brown, M. Mohiti, A. Pulis, R. Rasappan, D. J. Blair, S. Essafi, D. Leonori and V. K. Aggarwal*            
Stereospecific conversion of alcohols into pinacol boronic esters using lithiation–borylation methodology with pinacolborane
Chem. Commun. 2014, 50, 4053-4055.
This paper was highlighted in Synfacts.

15) M. Mohiti, C. Rabalakos, K. Feeney, D. Leonori and V. K. Aggarwal* 
Asymmetric Addition of Chiral Boron-Ate Complexes to Cyclic Imminium Ions
Chem. Sci. 2014, 5, 602.

14) G. Arena, C. Chun Chen , D. Leonori* and V. K. Aggarwal*
Concise Synthesis of (+)-allo-Kainic Acid via MgI2-Mediated Tandem Aziridine Opening-Formal [3+2] Cycloaddition
Org. Lett.. 2013, 15, 4250-4253.


Max Planck Institute for Colloids and Interfaces

13) D. Leonori and P. H. Seeberger* 
De Novo Synthesis of D- and L-Fucosamine Containing Disaccharides
Beilstein J. Org. Chem. 2013, 9, 332-341.

12) D. Leonori and P. H. Seeberger* 
De Novo Synthesis of the Bacterial 2-Amino-2,6-Dideoxy Sugar Building Blocks D-Fucosamine, D-Bacillosamine, and D-Xylo-6-deoxy-4-ketohexosamine
Org. Lett. 2012, 14, 4954-4957.


RWTH-Aachen University

11) M. Rueping,* R. M. Koenigs, K. Poscharny, D. C. Fabry, D. Leonori and C. Vila 
Dual Catalysis: Combination of Photocatalytic Aerobic Oxidation and Metal Catalyzed Alkynylation Reactions – C-C-Bond Formation Using Visible Light
Chem. Eur. J. 2012, 18, 5170-5174.

10) M. Rueping,* D. Leonori and T. Poisson 
Visible Light Mediated Azomethine Ylides Formation and [3+2] Cycloadditions    
Chem. Commun. 2011, 47, 9615-9617.


University of Sheffield

9) E. J. Cochrane, D. Leonori, A. A. Hassal and I. Coldham*
Synthesis and kinetic resolution of N-Boc-2-arylpiperidines
Chem. Commun. 2014, 50, 9910-9913.


8) X. Li, D. Leonori, N. S. Sheikh and I. Coldham* 
Synthesis of 1-Substituted Tetrahydroisoquinolines by Lithiation and Electrophilic Quenching Guided by In Situ IR and NMR Spectroscopy and Application to the Synthesis of Salsolidine, Carnegine and Laudanosine
Chem. Eur. J. 2013, 19, 7724-7730.

7) N. S. Sheikh, D. Leonori, G. Barker, J. Firth, K. Campos, P. O'Brien* and I. Coldham* 
An Experimental and In Situ IR Spectroscopic Study of the Lithiation–Substitution of N-Boc 2-phenylpyrrolidine and piperidine: Controlling the Formation of Quaternary Stereocenters
J. Am. Chem. Soc. 2012, 134, 5300.

6) I. Coldham* and D. Leonori 
Regioselective and Stereoselective Copper(I)-Promoted Allylation and Conjugate Addition of N-Boc-2-lithiopyrrolidine and N-Boc-2-lithiopiperidine
J. Org. Chem. 2010, 75, 4069-4077.


5) I. Coldham,* S. Raimbault, D. T. E. Whittaker, P. T. Chovatia, D. Leonori, J. J. Patel and N. S. Sheikh 
Asymmetric Substitutions of 2-Lithiated N-Boc-piperidine and N-Boc-azepine by Dynamic Resolution
Chem. Eur. J. 2010, 16, 4082-4090.

4) D. Leonori and I. Coldham* 
Direct Preparation of 7-Allyl and 7-Aryl-indoline
Adv. Synth. Catal. 2009, 351, 2619-2623.

3) I. Coldham,* D. Leonori, T. K. Beng and R. E. Gawley* 
The Barrier to Enantiomerization and Dynamic Resolution of N-Boc-2-lithiopiperidine and the Effect of TMEDA 
Chem. Commun. 2009, 5239-5241.

2) I. Coldham,* S. Raimbault, P. T. Chovatia, J. J. Patel, D. Leonori, N. S. Sheikh and David T. E. Whittaker 
Dynamic Resolution of N-Boc-2-lithiopiperidine 
Chem. Commun. 2008, 4174-4176.

1) I. Coldham* and D. Leonori 
Synthesis of 2-Arylpiperidines by Palladium Couplings of Aryl Bromides with Organozinc Species Derived from Deprotonation of N-Boc-Piperidine 
Org. Lett. 2008, 10, 3923-3925.
 

Book Chapters:

3) D. Leonori and V. K. Aggarwal 
Stereospecific Couplings of Secondary and Tertiary Boronic esters 
Topics in Organometallic Chemistry, 2014, accepted.

2) C. G. Watson, P. J. Unsworth, D. Leonori and V. K. Aggarwal 
Lithium-Boron Chemistry: A Synergistic Strategy in Modern Synthesis 
Wiley, Editors: V. Capriati, R. Luisi, 2014.

1) T. Chinnusamy, K. Feeney, C. G. Watson, D. Leonori and V. K. Aggarwal 
Oxidations of Carbon–Boron Bonds 
Comprehensive Organic Synthesis II, Elsevier, Editors: P. Knochel, G. Molander, 2014.





THE GROUP

RESEARCH

PUBLICATIONS

DANIELE

CONTACTS

Copyright© 2015